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Stem Cell Research

Embryonic stem cells accrue genetic changes

Published in Gene Therapy Weekly, September 29th, 2005

An international team of researchers has discovered that human embryonic stem cell lines accumulate changes in their genetic material over time.

The findings do not limit the utility of the cells for some types of research or for some future clinical applications, the researchers say, but draw attention to the need to closely monitor stem cell lines for genetic changes and to study how these alterations affect the cells' behavior. The researchers' work is described in the Sept. 4 online edition of Nature Genetics.

"This is just the first step," says Aravinda Chakravarti, PhD, one of the research team's leaders and professor and director of the...

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