Vaccine Delivery

Degradable copolymers developed as novel gene carriers

Published in Gene Therapy Weekly, September 29th, 2005

Researchers have developed degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers.

"An ideal gene carrier requires both safety and transfection efficiency. Polyethylenimine (PEI) is a well-known cationic polymer, which has high transfection efficiency owing to its buffering capacity. But it has been reported that PEI is cytotoxic in many cell lines and non-degradable. In this study, we synthesized degradable PEI-alt-poly(ethylene glycol) (PEG) copolymers using Michael-type addition reactions as a new gene carrier and characterized them," scientists in South Korea report.

"These copolymers were complexed with plasmid...

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Source: Gene Therapy Weekly (2005-09-29)

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