Gene Research

Epigenetic activity silences Rb2/P130 gene in lung cancer, retinoblastoma cells

Published in Gene Therapy Weekly, October 6th, 2005

The attaching of methyl - or chemical - groups onto DNA sequences within the tumor suppressing gene Rb2/p130 can cause the gene to cease functioning in non-small lung cancer cells (NSLC) and retinoblastoma cells, researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine and Italy's University of Siena have discovered.

Their findings are reported in two studies: "Tumor-specific exon 1 mutations could be the 'hit event' predisposing Rb2/p130 gene to epigenetic silencing in lung cancer" and "Genetic and epigenetic alterations of RB2/p130 tumor suppressor gene in human sporadic retinoblastoma: implications for pathogenesis and...

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Source: Gene Therapy Weekly (2005-10-06)

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