Published in Gene Therapy Weekly, October 13th, 2005
According to recent research published in the British Journal Of Cancer, "GSTP1 and MRP1 are overexpressed in melanoma, a skin cancer notoriously resistant to all current modalities of cancer therapy. To investigate the involvement of these detoxifying enzymes in the drug resistance of melanoma, an inducible (Tet-On system) antisense (AS) RNA strategy was used to specifically inhibit GSTP1 expression in A375 cells, a human melanoma...
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