Published in Gene Therapy Weekly, October 13th, 2005
"Chromosomal instability (CIN) is a cytogenetic hallmark of human cancers. Increasing evidence suggests that impairment of mitotic checkpoint is causally associated with CIN," scientists writing in the journal Molecular Carcinogenesis report.
"CHFR is one of the mitotic checkpoint regulators and it delays chromosome condensation in response to mitotic stress. Epigenetic inactivation of CHFR through promoter CpG hypermethylation may lead to CIN and has been reported in several human cancers," recount H.W. Cheung and colleagues,...
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