Lymphoma

STAT5 is a modifier of interleukin-7-induced lymphomas

Published in Gene Therapy Weekly, October 20th, 2005

According to recent research from Canada, "The requirement for receptor components and the signaling effector, signal transducer and activator of transcription (STAT) 5A/5B, was assessed genetically in a lymphoma development model induced by interleukin-7 (IL-7).

"This growth factor for T- and B-cell progenitors and mature lymphocytes activates survival and proliferative pathways including Bcl-2, phosphatidylinositol-3 kinase and STAT5."

"Overexpression of IL-7 in vivo causes early mortality from lymphoma development. Mice overexpressing IL-7 that were heterozygous for the IL-7R alpha subunit showed improved survival compared to wild-type...

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Source: Gene Therapy Weekly (2005-10-20)

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