Acute Myeloid Leukemia

BMI-1 is highly expressed in MO-subtype acute myeloid leukemia

Published in Gene Therapy Weekly, October 20th, 2005

BMI-1 is highly expressed in MO-subtype acute myeloid leukemia.

"Recent studies have suggested that one of the polycomb group genes, BMI-1, has an important role in the maintenance of normal and leukemic stem cells by repressing the INK4a/ARFlocus.

"Here, we quantitatively examined BMI-1 expression level in samples from patients with acute myeloid leukemia (AML) and other hematologic malignancies," scientists writing in the International Journal of Hematology report.

"Moderate to high BMI-1 expression was detected in AML patients, and the BMI-1 expression levels in AML samples were significantly higher than in normal bone...

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Source: Gene Therapy Weekly (2005-10-20)

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