Allergy Medicine

T cells induced by Foxp3-retrovirus infection control contact allergy

Published in Gene Therapy Weekly, October 20th, 2005

In vitro-generated regulatory T cells induced by Foxp3-retrovirus infection control murine contact allergy and systemic autoimmunity.

"Regulatory T cells are promising candidates for the modulation of inflammation and autoimmunity. To generate regulatory T cells in vitro, we have infected naive CD4+ CD25 T cells with a retrovirus encoding the transcription factor Foxp3. Foxp3-infected T cells are similar to naturally occurring regulatory T cells as evidenced by surface marker expression and function. To investigate the effects of Foxp3-infected T cells on contact hypersensitivity (CHS) responses, sensitized mice were injected with Foxp3-or control virus-infected T...

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Source: Gene Therapy Weekly (2005-10-20)

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