Stem Cell Research
p63 regulates commitment to prostate cell lineage
Published in Gene Therapy Weekly, October 27th, 2005
"Molecular mechanisms underlying prostate and urothelial development remain unclear. This situation presents major limitations in identifying the cell type(s) and molecular events involved in the development of prostate and bladder cancer," scientists in the United States report.
"It has been shown that mice lacking the basal cell marker p63 present several epithelial defects, including epidermis and prostate buds agenesis and urothelial abnormalities.
"Here, we use the p63-/-mouse as a tool to define cell lineages in the prostate epithelium and urothelium. By complementing...
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Source: Gene Therapy Weekly (2005-10-27)
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