Immunotherapy

The origin of regulatory T cells that "police" and protect the body is revealed

Published in Gene Therapy Weekly, November 3rd, 2005

More than 150 years after the discovery of Hassall's corpuscles in 1849, the function of these round blobs of cells in the human thymus gland has now been explained. The answer, in turn, ends an intense hunt for the origin of regulatory T cells that has been under way for years.

Reporting in the Aug. 25 issue of Nature, researchers at The University of Texas M.D. Anderson Cancer Center found that Hassall's corpuscles produce chemical signals that instruct dendritic cells in the thymus to induce development of these regulatory T cells - the critically important immune system cells that patrol the body looking for "bad' T cells that can produce autoimmune...

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Source: Gene Therapy Weekly (2005-11-03)

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