Published in Gene Therapy Weekly, November 3rd, 2005
According to recent research from Canada, "Selective gene expression in neurons is still a challenge. We have developed several expression vectors using a combination of neuron restrictive silencer elements (NRSEs), hypoxia responsive elements (HREs) and CMV minimal promoter (CMVmp)."
D. Huang and associates at the National Research Council in Ottawa, Canada explained, "These elements were packaged into replication defective adenovirus to target gene expression selectively in neurons in a hypoxia-regulated manner....
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