RNA Research

New gene regulation mechanism discovered

Published in Gene Therapy Weekly, November 10th, 2005

Researchers at Cold Spring Harbor Laboratory have discovered a new kind of messenger RNA molecule that is converted from non-protein coding status to protein coding status in response to cellular stress such as viral infection.

The discovery reveals a rapid response, "cut and run" mechanism that is likely to control the expression of many genes in humans and a variety of other organisms. A deeper understanding of this mechanism is likely to have broad implications for biology and biomedical research.

The central dogma of molecular biology holds that the DNA of genes is "transcribed" into messenger RNA and messenger RNA is "translated" into protein....

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Source: Gene Therapy Weekly (2005-11-10)

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