Genetics & Genomics
Hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression
Published in Gene Therapy Weekly, November 24th, 2005
"Runt-related transcription factor 3 (RUNX3) has been recognized as a tumor suppressor gene in gastric cancer because its expression level was reduced or disappeared due to epigenetic changes. To evaluate the usefulness of the RUNX3 gene as a biomarker of lung cancer, we have analyzed the expression of the RUNX3 gene in 15 lung cancer cell lines by real-time reverse transcription-polymerase chain reaction (RT-PCR), and demonstrated that RUNX3 gene expression was reduced or disappeared in all cell lines examined (100%)," researchers in...
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Source: Gene Therapy Weekly (2005-11-24)
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