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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . December 8th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Atherosclerosis - Studies show apo A-I Milano gene transfer cuts atherosclerotic plaque

Cancer Therapy - Gene therapy with sonoporation is feasible for hepatocellular carcinoma

Cancer Therapy - Somatostatin receptor transfection inhibits Panc-1 cell proliferation

Genetics & Genomics - A thermoresponsive copolymer vector is suitable for gene transfection

Pulmonary Medicine - Bronchopulmonary dysplasia models thrived after receiving proangiogenic gene therapy

Alzheimer Disease - 3-D structure of Alzheimer disease filament solved by researchers

Apoptosis - Caspase-9 is regulated in glucocorticoid-induced apoptosis

Apoptosis - Rho GDP dissociation inhibitor protects cancer cells against apoptosis

Apoptosis - TAK1 blockage sensitizes cells to apoptosis and affects tumor necrosis target genes

Breast Cancer - Hyaluronan synthase suppression inhibits breast cancer tumorigenesis

Breast Cancer - Immunity to breast cancer achieved using transfected fibroblasts

Breast Cancer - Protein marker reported to be associated with positive outcomes in invasive breast cancer

Business & Finance - Biopharmaceutical company reports net loss of $10.1 million in third quarter

Cancer Gene Therapy - Chronic gene delivery of interferon-inducible protein suppresses tumor growth

Cancer Gene Therapy - Gene therapy may purge leukemia cells from hematopoietic progenitor cells

Cancer Therapy - Advances evident in glioma molecular analysis and characterization

Cancer Therapy - Gas-filled microparticles and sonoporation are effective against tumors

Cancer Therapy - Gene therapy with histone deacetylase inhibitor enhances transgene expression

Cancer Therapy - HSV-based gene therapy enhances mitomycin efficacy in bladder cell carcinoma

Cancer Therapy - Inactivation of p53 sensitized astrocytic glioma cells to cancer drugs

Cancer Therapy - Melanoma-specific expression achieved in first-generation adenoviral vectors

Cancer Therapy - RNAi-mediated knockdown restores imatinib sensitivity in resistant CML cell lines

Cancer Therapy - Telomerase is synergistically down regulated in squamous cell carcinoma cells

Cancer Therapy - Virus-mediated metalloproteinase inhibition does not alter antitumor efficacy

Cancer Therapy - p53 protein transduction therapy facilitates glioma cells' anti-cancer effect

Cancer Vaccines - Oncolytic vaccinia viruses show promise in treatment of cancer

Cardiology - Renin-angiotensin system antagonists counteract myocardial angiogenesis in the normal heart

Cervical Cancer - New gene silencing for cervical cancer proposed by researchers

Collaborations - Researchers introduce molecular therapy for heart failure

DNA Research - Antisense knockdown of isoquinoline binding protein achieved in C6 glioma cell line

DNA Research - Genomic imprinting recapitulated in the human beta-globin locus

DNA Research - Sp1 and Sp3 regulate basal transcription of the human CYP2F1 gene

DNA Research - Systemic antisense oligodeoxynucleotide administration targets tumor growth

DNA Research - Triple helix-forming oligonucleotides conjugate to topoisomerase II inhibitors

Diagnostics - Test developed for detection of major human respiratory viruses

Disease Associations - A human mineral dust-induced gene is a cell growth regulating gene associated with lung cancer

Disease Associations - Altered axonal architecture slows amyotrophic lateral sclerosis

Gene Research - Recombinant adeno-associated virus vector expression can be enhanced in the lung

Gene Research - VP22 does not significantly enhance enzyme prodrug cancer gene therapy

Genetics & Genomics - Expert panel makes recommendations for DNA-based identification after mass disasters

Genetics & Genomics - Gene thought to influence perception gene was important in human evolution, scientists say

Genetics & Genomics - MC4R gene tissue specific expression requires one kb of the 5' flanking sequence

Genetics & Genomics - Mutations in the Braf gene predict sensitivity to novel class of cancer drugs

Genetics & Genomics - Natural antisense mRNAs inhibit hyaluronan biosynthesis and cell proliferation

Genetics & Genomics - Pituitary adenoma differential gene expression is detected by array analysis

Genetics & Genomics - System reported for inducible gene expression in retinal ganglion cells

Growth Hormone Therapy - Animal models for growth hormone gene therapy are reviewed

HIV/AIDS Vaccine - TRIM5 alpharh expression restricts HIV-1 infection in CD34+-cell-derived macrophages

Hepatitis B Virus - Stable inhibition of hepatitis B virus proteins is achieved by viral vector RNA

Hepatitis E Virus - Novel human hepatitis E virus (HEV) may be seroprevalent in Korea

Leukemia Vaccine - Lentivirus conjugation to paramagnetic particles allows infection of leukemia cells

Lung Cancer - Aberrant methylation of FBN2 detected in human non-small cell lung cancer

Melanoma - Combined effects evident in melanoma drug resistance

Nanotechnology - Monoclonal antibody-coated nanotubes may offer cost-effective way to identify cancer cells

Nanotechnology - Nanodelivery systems target primary and metastatic tumors

Nanotechnology - Scientists create a new way to study T cell signaling

Neuroscience - A transcriptional regulatory strategy may achieve neovascularization after cerebral ischemia

Neuroscience - Number, ratio of serotonin receptors found to influence brain's response to fear and stress

Neuroscience - siRNA-mediated gene knockdown is a useful strategy to study gene function

Parkinson Disease - A new drug target is identified for fighting Parkinson disease

Parkinson Disease - Parkinson disease, ALS, and stroke symptoms may be preventable, according to new studies

Patents - U.S. patent granted for system to measure normal range of gene expression

Stem Cell Differentiation - Inhibition of AF116909 gene expression enhances the differentiation of neural stem cells

Stem Cell Research - IRES technology license expanded for gene expression in mice, stem cells

Tuberculosis Vaccine - Advances in adenovirus- and poxvirus-vectored TB vaccines are reviewed

Vector Development - HSV-1-derived vectors for gene transfer and gene therapy are reviewed

Virology - Epstein-Barr virus LMP1 initiates cell growth and apoptosis inhibition in nasopharyngeal carcinoma

Virology - Herpes simplex fusions produce poor intercellular transport proliferation

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