Atherosclerosis

Studies show apo A-I Milano gene transfer cuts atherosclerotic plaque

Published in Gene Therapy Weekly, December 8th, 2005

Cardiology researchers at Cedars-Sinai Medical Center have found that a single injection of a harmless virus engineered to carry a beneficial, mutant gene enabled animals to manufacture their own supply of the gene's protein product that protects against plaque buildup in blood vessels.

As a result, the amount of plaque was significantly reduced, as was an immune reaction that can lead to plaque buildup and rupture, which can cause a blocked artery and heart attack or stroke.

The researchers are pursuing a variety of approaches to interrupt the complex processes leading to plaque formation and rupture, seeking new ways to treat and even prevent...

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Source: Gene Therapy Weekly (2005-12-08)

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