Published in Gene Therapy Weekly, December 8th, 2005
"Resistance to therapeutic drugs is a frequent phenomenon in hematologic malignancies, causing treatment failure in patients with leukemias and lymphomas. Overexpression of the multidrug-resistance gene (MDR-1) and its translational product PgP represents one mechanism of fatal drug resistance," wrote H. Rumpold and colleagues, Medical University of Innsbruck.
"We constructed a nonviral, transposon-based vector system for the stable knockdown of...
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