Cancer Therapy

Somatostatin receptor transfection inhibits Panc-1 cell proliferation

Published in Gene Therapy Weekly, December 8th, 2005

Recent research from the United States has documented that transfection of somatostatin receptor (SSTR)-1 and SSTR-2 inhibits pancreatic cancer cell line (Panc)-1 cell proliferation and renders Panc-1 cells responsive to somatostatin analogue.

"Somatostatin inhibits cell proliferation through interaction with its cellular receptor, SSTR. We have previously demonstrated that overexpression of individual SSTR-1 or SSTR-2 genes in receptor-negative pancreatic cancer cells inhibited cell proliferation."

"We hypothesize that reintroduction of SSTR genes back into pancreatic cancer cells might be an effective gene therapy strategy for pancreatic cancer,"...

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Source: Gene Therapy Weekly (2005-12-08)

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