Published in Gene Therapy Weekly, December 8th, 2005
"A carboxyl-terminated N-isopropylacrylamide/VL copolymer was prepared and coupled with chitosan (molecular weight=2000) to produce a PNVLCS vector. The aqueous solution of PNVLCS displayed an obvious thermoresponsive behavior with a lower critical solution temperature (LCST) about 26 degrees C," wrote S.J. Sun and colleagues, Tianjin University.
"Transmission electron microscopy (TEM) showed that the size of PNVLCS/DNA complexes varied with charge ratios (+/-), and the smaller nanoparticles...
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