Parkinson Disease

A new drug target is identified for fighting Parkinson disease

Published in Gene Therapy Weekly, December 8th, 2005

Researchers at Johns Hopkins Institute for Cell Engineering (ICE) have discovered a protein that could be the best new target in the fight against Parkinson disease since the brain-damaging condition was first tied to loss of the brain chemical dopamine.

Over the past year, the gene for this protein, called LRRK2 (pronounced "lark-2"), had emerged as perhaps the most common genetic cause of both familial and unpredictable cases of Parkinson disease. Until now, however, no one knew for sure what the LRRK2 protein did in brain cells or whether interfering with it would be possible.

Now, after studying the protein in the lab, Johns Hopkins researchers...

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Source: Gene Therapy Weekly (2005-12-08)

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