Developmental Biology

Cytokine-dependent regulation of anion transporter gene transactivators shown

Published in Gene Therapy Weekly, December 15th, 2005

Recent research from Germany has documented the cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver.

"Proinflammatory cytokines such as TNF-alpha and IL-1 beta lead to downregulation of hepatic organic anion transporters in cholestasis. This adapted response is transcriptionally mediated by nuclear hormone receptors and liver-specific transcription factors."

"Because little is known in vivo about cytokine-dependent regulatory events, mice were treated with either TNF-alpha or IL-1 beta for up to 16 h. Transporter mRNA expression was determined by Northern blot analysis, nuclear activity, and...

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Source: Gene Therapy Weekly (2005-12-15)

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