Published in Gene Therapy Weekly, December 15th, 2005
"Proinflammatory cytokines such as TNF-alpha and IL-1 beta lead to downregulation of hepatic organic anion transporters in cholestasis. This adapted response is transcriptionally mediated by nuclear hormone receptors and liver-specific transcription factors."
"Because little is known in vivo about cytokine-dependent regulatory events, mice were treated with either TNF-alpha or IL-1 beta for up to 16 h. Transporter mRNA expression was determined by Northern blot analysis, nuclear activity, and...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.