Published in Gene Therapy Weekly, December 15th, 2005
"Cysteinyl leukotrienes (cysLTs) play important roles in bronchial asthma, and can mediate bronchial smooth muscle constriction and increase mucous secretion, vascular permeability and cellular infiltration. We identified a novel heterozygous single-nucleotide substitution 10G > A (Glu-4-Lys) in the first exon of the leukotriene C4 synthase gene (LTC4S)."
"This substitution was detected in 5 of 141 allergic patients, but not in 110 nonallergic subjects. There was a difference in the...
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