Disease Associations

A single-nucleotide substitution is associated with allergic diseases

Published in Gene Therapy Weekly, December 15th, 2005

Recent research from Japan has reported on a novel single-nucleotide substitution, Glu-4-Lys, in the leukotriene C4 synthase gene associated with allergic diseases.

"Cysteinyl leukotrienes (cysLTs) play important roles in bronchial asthma, and can mediate bronchial smooth muscle constriction and increase mucous secretion, vascular permeability and cellular infiltration. We identified a novel heterozygous single-nucleotide substitution 10G > A (Glu-4-Lys) in the first exon of the leukotriene C4 synthase gene (LTC4S)."

"This substitution was detected in 5 of 141 allergic patients, but not in 110 nonallergic subjects. There was a difference in the...

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Source: Gene Therapy Weekly (2005-12-15)

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