Disease Associations

Interaction with blood components is crucial in gene transfer

Published in Gene Therapy Weekly, December 15th, 2005

According to a study from Japan, interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex.

"In this study," wrote S. Fumoto and colleagues, Kyoto University, "we evaluated the effect of blood components (whole blood and serum) on asialoglycoprotein receptor-mediated in vivo gene transfer."

"The hepatic transfection activity of galactosylated lipoplex preincubated with serum was approximately 10 times higher than that without incubation after intraportal injection in mice. However, preincubation with whole blood significantly reduced hepatic transfection...

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Source: Gene Therapy Weekly (2005-12-15)

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