Published in Gene Therapy Weekly, December 15th, 2005
B. Gonzales and colleagues, Baylor College of Medicine, wrote, "TCS is an autosomal dominant disorder of craniofacial development caused by mutations in the TCOF1 gene, which encodes the nucleolar phosphoprotein treacle. We previously reported a function for mammalian treacle in ribosomal DNA gene transcription by its interaction with upstream binding factor."
"As an initial step in the development of a TCS model for frog the cDNA that encodes the Xenopus laevis treacle...
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