Gene Therapy

Xenopus orthologue of the Treacher Collins syndrome gene product cloned

Published in Gene Therapy Weekly, December 15th, 2005

A study from the United States has described the cloning and functional characterization of the Xenopus orthologue of the Treacher Collins syndrome (TCS) gene product TCOF1.

B. Gonzales and colleagues, Baylor College of Medicine, wrote, "TCS is an autosomal dominant disorder of craniofacial development caused by mutations in the TCOF1 gene, which encodes the nucleolar phosphoprotein treacle. We previously reported a function for mammalian treacle in ribosomal DNA gene transcription by its interaction with upstream binding factor."

"As an initial step in the development of a TCS model for frog the cDNA that encodes the Xenopus laevis treacle...

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Source: Gene Therapy Weekly (2005-12-15)

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