Proteomics
Downregulation of c-myc protein occurs by siRNA-mediated silencing of DNA-PKcs in HeLa cells
Published in Gene Therapy Weekly, December 15th, 2005
"DNA-dependent protein kinase (DNA-PK) has been intensively investigated for its roles in the nonhomologous end-joining (NHEJ) pathway of DNA double-strand break repair and maintenance of genomic stability. Its catalytic subunit, DNA-PKcs, a serine/threonine protein kinase, has recently been reported to be overexpressed in various human cancers, but its significance is unclear."
"In our study," wrote J. An and colleagues, Beijing Institute of Radiation Medicine, "we synthesized 3 small interfering RNA...
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Source: Gene Therapy Weekly (2005-12-15)
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