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Vaccine Vector

Biocompatible polymer enhances transfection efficiency of HVJ envelope vector

Published in Gene Therapy Weekly, December 15th, 2005

A biocompatible polymer enhances the in vitro and in vivo transfection efficiency of an HVJ envelope vector.

According to a study from Japan, "Vector development is critical for the advancement of human gene therapy. However, the use of viral vectors raises many safety concerns and most non-viral methods are less efficient for gene transfer. One of the breakthroughs in vector technology is the combination of the vector with various polymers. HVJ (hemagglutinating virus of Japan) envelope vector (HVJ-E) has been developed as a versatile gene transfer vector. In this study, we combined HVJ-E with cationized gelatin to make it a more powerful tool and assessed its...

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