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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . December 22nd, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Biomedical Engineering - Chimeric antibody is expressed in mammalian cells using a dicistronic expression vector

DNA Research - Quercetin inhibition of iNOS gene expression is mediated by the inhibition of microglial factors

DNA Research - Simple cationic peptide motif allows delivery of antisense peptide nucleic acid

Gene Research - Antibiotic marker cassettes for gene disruption and marker switching constructed

Transplantation Medicine - Actin cytoskeleton regulator depletion suppresses cardiac allograft rejection

Allergy & Immunology - Promoter polymorphisms are associated with increased risk of atopic dermatitis

Alzheimer Disease - CD40 ligation in microglia perturbs genes associated with amyloid protein

Antibacterial Agents - Porcine peptidoglycan recognition proteins are involved in antimicrobial peptide expression

Antibacterial Agents - Vancomycin resistance gene transfer occurs between enterococci of human origin

Apoptosis - The BAD protein integrates survival signaling in tumor cells

Arteriogenesis - Vector encoding sphingosine kinase boosts revascularization in rabbit ischemic limbs

Atherosclerosis - Researchers' data advance atherosclerosis research

Breast Cancer -  CHEK2*1100delC allele imparts high risk for familial breast cancer

Business & Finance - Maker of gene-transfer therapy products reports third-quarter revenues of $21,000

Cancer Gene Therapy - Adoptive transfer of CD4+ helper T cells induces tumor rejection

Cancer Gene Therapy - Clusterin is a therapeutic target for radiation sensitization in lung cancer

Cancer Gene Therapy - Human leukemia cells can be eliminated by gene-transduced human T cells

Cancer Gene Therapy - RNA interference in cervical cancer produces increased sensitivity to cisplatin

Cancer Gene Therapy - Transduced peripheral blood lymphocytes recognize fresh human tumor

Cancer Gene Therapy - Transfection suppresses tissue infiltration of B cell precursor leukemia cells

Cancer Risk Factors - Former breast/ovarian cancer patients have high risk of familial genetic mutation

Cancer Therapy - Chromosomal deletions in B-cell lymphoma identify candidate tumor suppressor genes

Cancer Therapy - IL-17 enhances angiogenic activity and growth of non-small cell lung cancer

Cancer Therapy - Telomerase antagonists inhibit tumor growth and increase hepatoma chemosensitivity

Cardiology - Cord blood stem cells and gene therapy combine to spur angiogenesis after myocardial infarction

Collaborations - Genomics company and Prolexys Pharmaceuticals partner to deliver pathway analysis tools

DNA Research - Modified sam1 gene obtained with rare codons through the use of extension PCR

Developmental Biology - Amyloid beta alters Akt activity and affects mitochondrial function

Developmental Biology - Induction of secretive bone morphogenetic protein 2 could promote osteogenetic differentiation

Developmental Biology - Werner syndrome is associated with gene misregulation

Diagnostics - LacZ transgenic mouse assay detects mutations in follicular granulosa cells

Drug Development - Agreement signed to develop process, manufacture AIDS vaccine candidate for trials

Gene Research -  Escherichia coli strains mimic a common polymorphism in the MTHFR gene

Gene Research - New web site offers online custom lentiviral vector design manufacturing services

Gene Therapy - Insulin receptor substrate-1 can be targeted for angiogenic inhibition

Geriatrics - Long-allele genotype of the serotonin transporter-linked gene is prevalent in centenarians

Hepatitis B Virus - Human hepatocyte chimera can be infected with genetically engineered Hepatitis B Virus

Hepatitis C Therapy - Host sphingolipid biosynthesis is a target for hepatitis C virus therapy

Hepatitis C Virus - Transient-replication assay allows quantitation of hepatitis C viral RNA replication

Heptatitis C Virus - Alpha interferon inhibits translation mediated by hepatitis C virus genotypes

Immunotherapy - Suppressor of cytokine signaling limits autoimmune potential of antigen-naive CD8 T cells

Infectious Diseases -  Giardia lamblia surface protein cytotoxicity is enzymatically controlled

Leukodystrophy - Data advance knowledge in leukodystrophy research

Mergers & Acquisitions - Swedish biotech acquires Nurel Therapeutics

Oncology - Reports add new data to oncology research

Prostate Cancer - Interim results show PSA response from drug with docetaxel, prednisone in HRPC

Transplantation Biology - Hepatic expression of ABC transporters does not correlate with biliary cholesterol secretion

Vaccine Delivery - Histidylated lipid-modified Sendai viral envelopes enhance membrane fusion

Vaccine Delivery - Packaging method of oligodeoxynucleotides using nanoparticles is developed

Vector Development - Hereditary persistence of fetal hemoglobin 2 enhancer increases onco-retrovirus vector expression

Virology - Proviral DNA viral load may be diagnostic for myelopathy/tropical spastic paraparesis

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