Biomedical Engineering
Chimeric antibody is expressed in mammalian cells using a dicistronic expression vector
Published in Gene Therapy Weekly, December 22nd, 2005
"A dicistronic expression vector was constructed for Chinese hamster ovary (CHO) cells that produce both selectable marker-DHFR (dihydrofolate reductase) gene and recombinant antibody cDNA from a single primary transcript via differential splicing."
"The vector was derived from a pDHL vector and contained the human constant region cDNA so that any human-mouse chimeric antibodies could be expressed," wrote K.H. Xiong and colleagues, Fourth Military Medical University.
"The expression...
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Source: Gene Therapy Weekly (2005-12-22)
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