Cancer Therapy
Chromosomal deletions in B-cell lymphoma identify candidate tumor suppressor genes
Published in Gene Therapy Weekly, December 22nd, 2005
"Deletions of chromosome 8p are a recurrent event in B-cell non-Hodgkin lymphoma (B-NHL), suggesting the presence of a tumor suppressor gene. We have characterized these deletions using comparative genomic hybridization to microarrays, fluorescence in situ hybridization (FISH) mapping, DNA sequencing, and functional studies," wrote F. Rubio-Moscardo and colleagues, University of Navarra.
"A minimal deleted region (MDR) of 600 kb was defined in chromosome 8p21.3, with one mantle cell lymphoma cell line (Z138)...
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Source: Gene Therapy Weekly (2005-12-22)
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