DNA Research
Simple cationic peptide motif allows delivery of antisense peptide nucleic acid
Published in Gene Therapy Weekly, December 22nd, 2005
"Improving cellular uptake and biodistribution remains one of the major obstacles for a successful and broad application of PNAs as antisense therapeutics. Recently, we reported the identification and functional characterization of an antisense PNA, which redirects splicing of murine CD40 pre-mRNA."
"In this context," wrote K. Albert-Shofer and colleagues, ISIS Pharmaceutical, "it was discovered that a simple octa(L-Lys) peptide covalently linked to the PNA is...
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Source: Gene Therapy Weekly (2005-12-22)
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