Transplantation Biology
Hepatic expression of ABC transporters does not correlate with biliary cholesterol secretion
Published in Gene Therapy Weekly, December 22nd, 2005
"The ABC-transporters ABCG5 and ABCG8 have been shown to mediate hepatic and intestinal excretion of cholesterol. In various (genetically modified) marine models, a strong relationship was found between hepatic expression of ABCG5/ABCG8 and biliary cholesterol content."
"Our study aimed to relate levels of hepatic expression of ABCG5 and ABCG8 to biliary excretion of cholesterol in man," wrote E. Geuken and colleagues,...
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Source: Gene Therapy Weekly (2005-12-22)
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