Alzheimer Disease
CD40 ligation in microglia perturbs genes associated with amyloid protein
Published in Gene Therapy Weekly, December 22nd, 2005
"Key pathological processes in Alzheimer disease (AD) include the accumulation of amyloid beta peptide (Abeta) which, in excess, triggers pathological cascades including widespread inflammation, partly reflected by chronic microglial activation."
"It has previously been suggested that CD40/CD40L interaction promotes AD like pathology in transgenic mice. Thus, amyloid burden, gliosis and hyperphosphorylation of tau are all reduced in transgenic models of AD lacking functional CD40L," wrote G. Aitghezala and...
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Source: Gene Therapy Weekly (2005-12-22)
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