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DNA Vaccine

High-speed chromatographic purification method for plasmid DNA is developed

Published in Gene Therapy Weekly, December 29th, 2005

Scientists have developed a method for the high-speed chromatographic purification of plasmid DNA using a customized biporous hydrophobic adsorbent.

According to recent research from China, "Interest in producing large quantities of plasmid DNA has recently increased as a result of the rapid evolution of gene therapy and DNA vaccines."

"Hydrophobic chromatography is a popular technique in the downstream processing of plasmid DNA. However, the low capacity and the high mass transfer resistance of most commercially available packings for bio-macromolecules limit their application in a large-scale process. In this work, a hydrophobic absorbent with wide...

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