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Hepatitis B Therapy

Genomic analysis conducted of anti-hepatitis B virus activity

Published in Gene Therapy Weekly, December 29th, 2005

A recent study from the People's Republic of China has reported on a genomic analysis of anti-hepatitis B virus (HBV) activity by small interfering RNA (siRNA) and lamivudine in stable HBV-producing cells.

"HBV causes acute and chronic hepatitis and hepatocellular carcinoma. siRNA and lamivudine have been shown to have anti-HBV effects through different mechanisms."

"However," wrote Y. Guo and colleagues, Tsing Hua University, "assessment of the genome-wide effects of siRNA and lamivudine on HBV-producing cell lines has not been reported, which may provide a clue to interrogate the HBV-cell interaction and to evaluate the siRNA's side effect as a...

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