Prostate Cancer Therapy

Apoptosis in human prostate cancer cells is induced by kinase activation

Published in Gene Therapy Weekly, December 29th, 2005

According to recent research from Japan, adenovirus-mediated overexpression of REIC/Dkk-3 selectively induces apoptosis in human prostate cancer cells through activation of c-Jun-NH2-kinase.

F. Abarzua and colleagues, Okayama University, wrote, "Alteration in genes which takes place during malignant conversion and progression could be potential targets for gene therapy."

"We previously identified REIC/Dkk-3 as a gene whose expression is reduced in many human cancers. Here, we showed that expression of REIC/Dkk-3 was consistently reduced in human prostate cancer tissues in a stage-dependent manner."

"Forced expression of REIC/Dkk-3...

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Source: Gene Therapy Weekly (2005-12-29)

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