Retinoblastoma

Suicide gene therapy is promising in the treatment of retinoblastoma tumor seeds

Published in Gene Therapy Weekly, January 5th, 2006

Investigators in the United States conducted a study that chronicled the response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir.

"To evaluate the feasibility and safety of adenovirus-mediated gene therapy as a treatment for tumor seeds in the vitreous of children with retinoblastoma," wrote P. Chevez-Barrios and colleagues, Baylor College of Medicine, "an Institutional Biosafety Committee-, Institutional Review Board; Recombinant DNA Advisory Committee-, and U.S. Food and Drug Administration-approved phase I study used intrapatient dose escalation of adenoviral vector containing a herpes simplex...

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Source: Gene Therapy Weekly (2006-01-05)

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