Vector Development

Calcium phosphate nanoparticles have been developed as nonviral vectors in gene therapy

Published in Gene Therapy Weekly, January 5th, 2006

Researchers have developed calcium phosphate nanoparticles as second-generation nonviral vectors in gene therapy.

According to a report from India, "Adverse effects of viral vectors, instability of naked DNA, cytotoxicity, and low transfection of cationic lipids, cationic polymers, and other synthetic vectors are currently severe limitations in gene therapy."

"In addition to targeting a specific cell type, an ideal nonviral vector must manifest an efficient endosomal escape, render sufficient protection of DNA in the cytosol and help provide an easy passage of cytosolic DNA to the nucleus. Virus-like size calcium phosphate nanoparticles have been...

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Source: Gene Therapy Weekly (2006-01-05)

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