Adenovirus Vector
Oncolytic adenovirus replicates selectively in tumors
Published in Gene Therapy Weekly, January 5th, 2006
According to recent research from the United States, "We have constructed a novel oncolytic adenovirus (Ad) vector, named VRX-011, in which the replication of the vector is targeted to cancer cells by the replacement of the wild-type Ad E4 promoter with the human telomerase reverse transcriptase (hTERT) promoter."
"Genes in the Ad E4 transcription unit are essential for Ad replication; therefore, VRX-011 will grow efficiently only in cells in which the hTERT promoter is active, that is, in a...
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Source: Gene Therapy Weekly (2006-01-05)
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