Cancer Gene Therapy
E2F-1 gene therapy up-regulates PKR and inhibits growth of leiomyosarcoma
Published in Gene Therapy Weekly, January 12th, 2006
"Overexpression of the transcription factor E2F-1 induces apoptosis in a variety of carcinoma cells and inactivates murine double minute protein 2, a factor associated with poor prognosis in soft tissue sarcomas."
S.A. Vorburger and colleagues, M.D. Anderson Cancer Center, wrote, "We have shown previously that the double-stranded RNA-activated protein kinase PKR plays an important role in mediating this apoptotic response in carcinoma cells to E2F-1."
"We...
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Source: Gene Therapy Weekly (2006-01-12)
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