Esophageal Cancer

Basic fibroblast growth factor risk for esophageal cancer is ameliorated

Published in Gene Therapy Weekly, January 12th, 2006

According to recent research published in the journal Clinical Cancer Research, basic fibroblast growth factor (FGF-2) overexpression is a risk factor for esophageal cancer recurrence and reduced survival, which is ameliorated by coexpression of the FGF-2 antisense gene.

"The basic FGF-2 gene is bidirectionally transcribed to generate overlapping sense and antisense (FGF-AS) mRNAs. FGF-AS has been implicated in the posttranscriptional regulation of FGF-2 expression."

"The aim of this study was to characterize FGF-2 and FGF-AS in esophageal cancer and to correlate their expression with clinicopathologic findings and outcome," wrote C. Barclay...

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Source: Gene Therapy Weekly (2006-01-12)

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