Gene Therapy

Retroviral suicide gene therapy achieves long-term survival in glioma

Published in Gene Therapy Weekly, January 12th, 2006

According to research from the United States, single-shot, multicycle suicide gene therapy by replication-competent retrovirus vectors achieves long-term survival benefit in experimental glioma.

"Achieving therapeutically efficacious levels of gene transfer in tumors has been a major obstacle for cancer gene therapy using replication-defective virus vectors. Recently, replicating viruses have emerged as attractive tools for cancer therapy, but generally achieve only transitory tumor regression."

"In contrast to other replicating virus systems, transduction by replication-competent retrovirus (RCR) vectors is efficient, tumor-selective, and...

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Source: Gene Therapy Weekly (2006-01-12)

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