Published in Gene Therapy Weekly, January 12th, 2006
"A pair of nuclear receptors, EcR and ultraspiracle (USP), heterodimerize and transduce ecdysteroid signals. The EcR and its nonsteroidal ligands are being developed for regulation of transgene expression in humans, animals and plants."
"In mammalian cells, EcR:USP heterodimers can function in the absence of ligand, but EcR/retinoid X receptor (EcR:RXR) heterodimers require the presence of ligand for activation," wrote S.R. Palli and colleagues of the University of Kentucky.
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