Ovarian Cancer

KiSS1 suppresses metastasis in human ovarian cancer

Published in Gene Therapy Weekly, January 12th, 2006

According to a study from the United States, KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C (PKC) alpha.

"Metastasis is a vital target for cancer treatment, since the majority of cancer patients die from metastatic, rather than the primary disease. KiSS1 has been identified as a metastasis suppressor gene in melanoma and breast carcinomas."

"We show here that KiSS1 is also a metastasis suppressor in human ovarian cancer," wrote Y. Jiang and colleagues, Cleveland Clinic Foundation.

"Overexpression of KiSS1 in ovarian cancer cells inhibits cell migration induced by serum or lysophosphatidic...

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Source: Gene Therapy Weekly (2006-01-12)

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