Prostate Cancer

Melastatine member is involved in channel activation in prostate cancer

Published in Gene Therapy Weekly, January 12th, 2006

Recent research from France has described a novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells.

"Recent cloning of a cold/menthol-sensitive TRPM8 channel (transient receptor potential melastatine family member 8) from rodent sensory neurons has provided the molecular basis for the cold sensation. Surprisingly, the human orthologue of rodent TRPM8 also appears to be strongly expressed in the prostate and in the prostate cancer-derived epithelial cell line, LNCaP."

"In this study," wrote S. Thebault and...

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Source: Gene Therapy Weekly (2006-01-12)

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