Published in Gene Therapy Weekly, January 12th, 2006
According to recent research from the United States, "Although adeno-associated virus (AAV)-mediated gene therapy has been hindered by the small viral packaging capacity of the vector, trans-splicing AAV vectors are able to package twice the size of the vector genome. Unfortunately, the efficiency of current trans-splicing vectors is very low. We show that rational design of the gene splitting site has a profound influence on trans-splicing vector-mediated gene expression."
"Using mRNA accumulation as a guide, we generated a set of efficient trans-splicing...
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