Inflammation
p53 regulates gene expression in chronic inflammatory stress
Published in Gene Therapy Weekly, January 19th, 2006
"Activation of the p53 network plays a central role in the inflammatory stress response associated with ulcerative colitis and may modulate cancer risk in patients afflicted with this chronic disease."
"Here," wrote F. Staib and colleagues, U.S. National Cancer Institute, "we describe the gene expression profiles associated with four microenvironmental components of the inflammatory response (NO*, H2 O2 , DNA replication arrest, and hypoxia) that result in p53 stabilization and activation."
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Source: Gene Therapy Weekly (2006-01-19)
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