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Macrophages

Induced interleukin-beta expression can be inhibited in macrophages

Published in Gene Therapy Weekly, January 19th, 2006

According to a study from France, extracellular human thioredoxin-1 (Trx-1) inhibits lipopolysaccharide-induced interleukin (IL)-1 beta expression in human monocyte-derived macrophages (HMDM).

"Oxidative stress plays an important role in atherosclerotic vascular disease, and several recent studies were focused on Trx-1 and its potential protective role against oxidative stress," wrote L. Billiet and colleagues, INSERM U545.

"Since HMDM are important cells in several inflammatory diseases including atherosclerosis, we conducted this study to evaluate the impact of extracellular recombinant human Trx-1 (rhTrx-1) on gene expression in...

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