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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . January 26th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Antisense Technology - Cell surface conjugates can be antisense blocked in Entamoeba histolytica

Epstein-Barr Virus - Proliferation of EBV-positive Burkitt lymphoma cells is inhibited by RNA interference

Gene Therapy - Antagomirs silence microRNAs

Gene Therapy - Recombinant antibodies deliver peptides for deletion of antigen-specific CD4+8+ thymocytes

Infectious Diseases - Induced expression of melittin suppresses Chlamydia and Mycoplasma infections

Alzheimer Disease - New findings in the area of Alzheimer Disease described

Antisense Technology - Nuclear receptor 5a2 functions in skeletal muscle organization

Apoptosis - Inhibited nuclear translocation overcomes apoptosis signaling defects in B-cell malignancies

Apoptosis - Inhibition of apoptosis triggers hepatocarcinogenesis

Apoptosis - Researchers describe findings in apoptosis studies

Biomedical Engineering - Transfected stromal cells improve the fate of healing bone grafts

Blood Cells - A Ser protease in blood cells regulates the melanization reaction in Drosophila

Breast Cancer - Breast cancer resistance protein may not be primarily involved in multiple myeloma

Breast Cancer - Faults in newly discovered breast stem cells may lead to tumors

Breast Cancer - New findings in Breast Cancer described

Breast Cancer - RNA interference in breast cancer cells alters differentiation and proliferation

Cancer Cells - Three-dimensional culture of melanoma cells impairs their immunorecognition

Cancer Research - Advances reported in development of oncolytic viruses for cancer treatment

Cancer Research - Results of in vitro bone marrow cancer cell study show gene technology effective

Cancer Research - U.S. DOD awards $1.5 million in research funding to Nebraska cancer center

Cancer Therapy - Antisense/radiation therapy effectively treats nasopharyngeal cancer

Cancer Therapy - Cytochrome modulation triggers apoptosis in tumor cells

Cancer Therapy - Findings describe new data in Cancer Therapy research

Cancer Therapy - Loss of the hSNF5 gene inactivates replicative senescence in rhabdoid tumors

Cancer Therapy - Melanoma differentiation-associated gene has diverse antitumor properties

Carcinogenesis - UV-induced mutant p53 and skin tumors analyzed by mutation spectra and induction kinetics

Cell Therapy - Autologous cells from fat tissue revive new vessel growth in ischemic limbs

Clear Cell Sarcoma - Up-regulation of neural markers detected in clear cell sarcoma of the kidney

Colon Cancer - Reports add new data to Colon Cancer research

DNA Research - Acidity and structure of nucleosome assembly protein mediate assembly of core particles

DNA Research - Loss of a splicing factor induces cell cycle arrest and apoptosis

DNA Research - Silencing Cenp-F prevents chromosome alignment and activates the spindle checkpoint

DNA Research - Werner protein protects nonproliferating cells from oxidative DNA damage

DNA Vaccines - Studies advance knowledge in DNA Vaccines research

Developmental Biology - Ocular lens development is regulated by Smad-interacting protein 1 involving Foxe3 activation

Developmental Biology - Slow muscle regulates the pattern of trunk neural crest migration in zebrafish

Diabetes Complications - Microangiopathy may influence normocytic normochromic anemia

Drug Development - A new RNA aptamer targeting alphavbeta3 integrin hinders endothelial cell growth and survival

Endocrinology - Phosphoinositide signaling controls beta-cell secretion in insulin exocytosis

Finance - Cancer-focused drug delivery company to raise about $15.8 million through equity funding

Gene Expression - A novel survival-related gene controls apoptosis and tumorigenesis

Gene Research - Small RNA regulates endothelial nitric oxide synthase

Gene Therapy - Effect of epidermal growth factor receptor inhibitors on gliomas studied

Helicobacter Pylori -  H. pylori conjugative transfer is mediated by relaxase and traG-like proteins

Hematology - Sickle cell disease corrected in human models using stem cell-based gene therapy

Hepatitis C Virus - Reports add new data to Hepatitis C Virus research

Hyperbilirubinemia - Delivery of naked plasmid DNA into muscle corrects hyperbilirubinemia

Hypertension - Relaxin increases cardiac output and reduces systemic arterial load

Immunoglobulins - MRE11/RAD50 cleaves DNA in an immunoglobulin gene diversification pathway

Infectious Diseases - Legionella acquires type IV secretion substrates via horizontal gene transfer

Leukemogenesis - MEK kinase 1 essential for Bcr-Abl-induced STAT3 and self-renewal activity in ESCs

Malaria - Clip domain Ser proteases function in the malaria vector Anopheles gambiae

Marketing - Exaeris commences formal operations

Melanoma - O-6-benzylguanine and BCNU did not improve outcome of melanoma

Mergers & Acquisitions - Extensive gene therapy assets acquired

Muscular Dystrophy - Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, study finds

Neuroblastoma - Gene described that halts spread of aggressive childhood cancer

Neuroscience - Hippocampal plasticity-related proteins are regulated strain-dependently

Neuroscience - Neuronal differentiation is unaffected by the reduction of neuropathy target esterase

Neuroscience - Serotonin transporter gene polymorphisms influence cognitive abilities

Personnel - Bioactive peptides developer appoints Richard M. Cohen to its board of directors

Physiology - Decreased intestinal glucose transport revealed in absence of a kinase isoform

Physiology - Interleukin receptor antagonist purified

Product Licensing - Biopharmaceutical company licenses anti-sickling agent from Virginia Commonwealth

Prostate Cancer - Increased Hsp27 facilitates androgen-independent progression in prostate cancer

Prostate Cancer - Recent studies add new data to Prostate Cancer research

Proteomics - A large volume of oxygen can be dissolved in recombinant albumin clusters

Proteomics - Adiponectin represses gluconeogenesis independent of insulin in hepatocytes

Proteomics - Researchers' data advance proteomics research

Ribosomes - Assembly of the 30S ribosomal subunit utilizes different conformations

Smooth Muscle Cells - TRPC6 channels mediate Ca2+ signal generation in A7r5 smooth muscle cells

Stem Cell Research - Data show hair follicle stem cells rival embryonic stem cells in regenerative potential

Stroke - Recombinant factor VIIa is potentially useful for intracerebral hemorrhage

Tumors - Cytotoxic T cell functions are directly targeted during tumor evasion of immune surveillance

Ulcerative Colitis - New drug application filed with U.S. FDA on mesalamine treatment for ulcerative colitis

Vaccine Delivery - Amine groups in the structure of polymeric transfectant affect DNA delivery

Vaccine Delivery - Thiol-modified gelatin nanoparticles for intracellular DNA delivery have been developed

Vaccine Development - Turning off molecular "brake" boosts immune response in mouse model of HIV

Vaccine Vector - Membrane-based technology reduces purification time for viral vectors

Varicella-Zoster Virus - Small plaque varicella-zoster virus mutants are defective in viral gene expression

Vector Development - Intelligent polymers show promise as nonviral vectors

Vector Development - Researchers' findings advance Vector Development research

Vector Development - Review examines obstacles and advances in intracellular trafficking of retroviral vectors

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