Antisense Technology

Cell surface conjugates can be antisense blocked in Entamoeba histolytica

Published in Gene Therapy Weekly, January 26th, 2006

A study from India has chronicled the reduction of cell surface glycosylphosphatidylinositol (GPI) conjugates in Entamoeba histolytica by antisense blocking of E. histolytica GlcNAc-phosphatidylinositol deacetylase (PIG-L) expression.

"GPI-anchored molecules such as cell surface Gal/GaINAc lectin and proteophosphoglycans of the protozoan parasite E. histolytica are thought to be involved in pathogenesis. Here, we report the identification of genes that may be involved in the GPI biosynthetic pathway of E. histolytica by use of bioinformatic tools applied to the recently published genome sequence," wrote D. Vats and colleagues, Jawaharlal...

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Source: Gene Therapy Weekly (2006-01-26)

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