Epstein-Barr Virus

Proliferation of EBV-positive Burkitt lymphoma cells is inhibited by RNA interference

Published in Gene Therapy Weekly, January 26th, 2006

According to recent research from Japan, suppression of Epstein-Barr nuclear antigen 1 (EBNA1) by RNA interference (RNAi) inhibits proliferation of EBV-positive Burkitt lymphoma cells.

"Epstein-Barr virus (EBV) is associated with the development of several lymphoid and epithelial malignancies, including Burkitt lymphoma. The EBV latent protein EBNA1 is detectable in almost all types of EBV-associated tumors and is essential for replication and maintenance of the latent episome of EBV."

"We here examined whether the RNAi technique could be employed to suppress expression of EBNA1 in EBV-positive Burkitt lymphoma cells," wrote M. Hong and colleagues,...

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Source: Gene Therapy Weekly (2006-01-26)

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