DNA Research

Loss of a splicing factor induces cell cycle arrest and apoptosis

Published in Gene Therapy Weekly, January 26th, 2006

Research from the United States has reported that loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis but inhibits internucleosomal DNA fragmentation.

"ASF/SF2 is an SR protein splicing factor that participates in constitutive and alternative pre-mRNA splicing and is essential for cell viability," wrote X.L. Li and colleagues, Columbia University.

"Using a genetically modified chicken B-cell line, DT40-ASF, we now show that ASF/SF2 inactivation results in a G2-phase cell cycle arrest and subsequent programmed cell death."

"However, although several hallmarks of apoptosis are apparent, internucleosomal DNA...

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Source: Gene Therapy Weekly (2006-01-26)

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